Bacillus Strain with High Antifungal Activity

The strain YJP-111 with high antifungal activity was isolated from soils collected in Suwon, Korea, and identified as a Bacillus sp. YJP-111. A purified substance, shown by chromatography to be antibiotic against Penicillium italicum, was crystallized.

Isolation of Antibiotic

The substance was composed of oligosaccharides, with a molecular weight of 366 and a melting point of 155 - 157oC. It was identified as a novel antibiotic substance. The efficacy of this new antifungal substance was very strong in inhibiting the growth of the fungal pathogen, Penicillium italicum, which causes post-harvest diseases in orange and lily. No toxicity against fish was observed up to a concentration of 10 mg/L. Thus, this substance is considered to have low toxicity.

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